I don't have one particular favorite, but there are a few actors I generally "trust" based on their past work. When I see their names on a project I say to myself, "hey, that's going to be worth checking out." Patrick Stewart, LeVar Burton, Bruce Willis, Chris Reeve, are all on my "list of favorites," for lack of a better name.
Unfortunately a lot of the people on my list either don't do much acting any more or have passed away.