I hope to see a new Pikmin game on the Wii, really. Not just the re-releases of the Gamecube titles.

That's something they could do interesting things with, if they tried, I think. That said...I don't mind Nintendo doing things that are tried and true, but I'd like to see more innovation, too.
Though, I will be honest, and I must bring this up because of what I am...I really don't know if I want to see them try to revive the Mother franchise, one reason being the developer, Shigesato Itoi, has said he was done with it after Mother 3. The other being that I think it's done. I hate seeing things that should be done be revived for the sake of reviving it. On the other hand...if they did it RIGHT and made a new game more like the first two games instead of the third...it could be awesome. On one hand, I want them to do something with it, on the other I'd rather they leave it alone. I'm going to bet on the latter.