I was just reading something about this a few moments ago and my first reaction was no way would this work with a bunch of female Ghostbusters, however, on second thought it might have a shot.
I must admit to being partial to the original Ghostbuster cast and wanting them together again but since one of them has passed away now and it has been many, many years since they were together, and it seems for whatever reason almost impossible to get the remaining alive old gang together again, they are going to certainly have to do something new and fresh in an upcoming film. I remember reading when they were last talking about trying to get a 3rd Ghostbusters started that they kind of wanted to pass the torch along to a younger group of Ghostbusters and such. So, yeah, I could see it happening with female Ghostbusters who were probably somehow related to the original Ghostbusters from past movies. Although in my opinion there does need to be some type of male role involved to entice female movie goers to want to see the film more. Female Ghostbusters would be a good incentive to both a female and male audience but while guys may enjoy looking at the gals, the gals might enjoy some eye candy too, so to speak. Although if they just have the Stay Puft Marshmallow Man in the movie some how, that will be enough to make me happy. Love that dude, lol. I even still have my own Marshmallow Man toy figurine from the old movies!!